Doxycycline

Doxycycline has the same other tetracyclines effects. and it characterizes that its impact on gram-positive bacteria is double of other tetracyclines. It absorbs after oral use and its absorption isn't decreased by foods. 90% of it bonds to plasma, the highest rate compared with other tetracyclines. 
It extends to give minimum disposing level and max half live in plasma (13-23 hours). 
It is considered active against urinary tract, and kidney infections when the concentration in tissues is more important than the concentration in urine.  Don't use this product or use it with care in the cases of kidney failure or waxy liver. Colistin is little absorbed in the stomach, allowing a high concentration in the bowel. The corporation of these two antibiotics causes high effects against acute CRD and E. coli even when resisting other antibiotics such as Tylosin or Erythromycin.